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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11993 | MEK inhibitor | MEK | |
MEK inhibitor is a potent MEK inhibitor with antitumor potency. | |||
T28012 | MEK-IN-4 | MEK | |
MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer. | |||
T6843 | GDC-0623 | G-868,GDC0623,RG 7421,MEK inhibitor 1 | Apoptosis , MEK |
GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. | |||
T2508 | Binimetinib | ARRY-438162,ARRY-162,MEK162 | MEK , Autophagy |
Binimetinib (ARRY-162) (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay. | |||
T6152 | PD318088 | MEK | |
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. | |||
T6692 | TAK-733 | TAK733,TAK 733 | MEK |
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. | |||
T2708 | SL327 | SL 327,SL-327 | MEK , DNA/RNA Synthesis |
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier. | |||
T6785 | BI-847325 | Apoptosis , MEK , Aurora Kinase | |
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. | |||
T21295 | BIX02189 | BIX 02189 | ERK , MEK |
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM). | |||
T21635 | PD184161 | MEK | |
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1]. | |||
T2443 | CI-1040 | PD 184352 | Apoptosis , MEK |
CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM). | |||
TMS2181 | Trans-Zeatin | (E)-Zeatin | ERK , MEK , Endogenous Metabolite |
trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. | |||
T2623 | PD98059 | PD 98059 | ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy |
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. | |||
T7610 | GW284543 | UNC10225170 | MEK |
GW284543 (UNC10225170) is a selective inhibitor of MEK5 . | |||
T6189 | Mirdametinib | PD325901,PD0325901 | Apoptosis , MEK , Autophagy |
Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis. | |||
T21980 | PD 198306 | MEK | |
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1. | |||
T5412 | RO4987655 | CH4987655,RG7167 | MEK |
RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2). | |||
T6971 | Ro 5126766 | CH5126766,Avutometinib,VS-6766,RO5126766 | Raf , MEK |
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1. | |||
T6760 | APS-2-79 hydrochloride | APS-2-79 HCl,APS-2-79 | MEK , MAPK |
APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activ... | |||
T1144L | Lidocaine Hydrochloride hydrate | EGFR , Sodium Channel | |
Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property. |